Endocrine Abstracts

Background: Chronic anovulation constitutes one of the cardinal features of Polycystic Ovary Syndrome (PCOS) and Anti-Müllerian hormone (AMH), a granulosa cell product, is a well documented marker of anovulation. Recent data have shown that oxidative stress is involved in the pathophysiology of anovulation. A marker of oxidative stress, Advanced Glycosylated End products (AGEs), is implicated to the pathogenesis of the syndrome and have been localized with high intensity ...

In insulin resistant, young women with PCOS elevated serum AGEs and their receptor RAGE have been reported. The present study (approved by the local ethical committee) was undertaken to determine whether increased levels of serum AGEs in PCOS is a distinct finding compared with age- and BMI-matched women, presenting the isolated components of the syndrome and whether serum AGE levels were different among PCOS phenotypes. A total of 193 lean non-insulin resistant women were stu...